Definition of agitated depression Psychiatry. a severe depression accompanied by constant restlessness. See synonyms for agitated depression. About • Contact • Link to Infoplease • © 2000–2004 Pearson Online Medical Dictionary and glossary with medical definitions Agitated depression: A major depressive disorder with restlessness and motor excitement. Agitated depression was once called melancholia agitata This Article. Services. PubMed. Related Collections. Depression. Epidemiology. Article. Agitated Depression in Bipolar I Disorder: Prevalence, Phenomenology, and Outcome aimed to explore how prevalent agitated depression is in bipolar I disorder, whether those fulfilling Research Diagnostic Criteria for agitated depression. These 61 patients were Definition of agitated depression Psychiatry. a severe depression accompanied by constant restlessness. See synonyms for agitated depression. About • Contact • Link to Infoplease • © 2000–2004 Pearson dictionaries with English definitions that include the word agitated depression: Tip: Click on the first link on to go directly to a page where "agitated depression" is defined. - Cystic Fibrosis - Delirium - Depression - Dermatitis - Diabetes - Diverticulitis sleep disturbances. agitated depression, major depressive disorder with psychomotor agitation.