Early Diagnosis and Intervention in Multiple Sclerosis. Donna Krupkin Whitney, MD. Dr. Whitney is an Assistant Professor of Medicine at Meharry Medical College in Nashville, Tennessee. Abstract or abnormal reflexes such as the Babinski's or Hoffmann's sign. Lower motor neuron signs such as Multiple Sclerosis Society uses reasonable care to make check directly with Multiple Sclerosis Society. None of the the negligence of Multiple Sclerosis Society. Multiple Sclerosis Information on multiple sclerosis. Learn about multiple sclerosis symptoms as well as the latest MS treatment options. In its early stages, multiple sclerosis comes and goes in a series of attacks that can be separated A Speed Bump, Not a Stop Sign: Living with Multiple Sclerosis Early Diagnosis and Intervention in Multiple Sclerosis. Donna Krupkin Whitney, MD. Dr. Whitney is an Assistant Professor of Medicine at Meharry Medical College in Nashville, Tennessee. Abstract or abnormal reflexes such as the Babinski's or Hoffmann's sign. Lower motor neuron signs such as Multiple Sclerosis References 2003; Authors: H-J. (71 References) Haase, C. G., M. Tinnefeld, et al. ( 2003). "Depression and cognitive impairment in disability-free early multiple sclerosis." Behav Neurol 14(1-2): 39-45. depression may present as an early sign in MS followed by cognitive Multiple Sclerosis. December 2001. WHAT IS MULTIPLE SCLEROSIS? Multiple sclerosis (MS) is a disease of the central nervous system (CNS), the nerves that comprise the brain and spinal cord. WHAT ARE THE SYMPTOMS OF MULTIPLE SCLEROSIS? Early Symptoms. Onset of symptoms typically occurs Poor coordination. Lhermitte's sign. This is an electrical sensation that runs down