Cleveland Clinic: Psychotic Depression. Depression Psychotic depression combines depression with hallucinations or Find out how to recognize psychotic depression. webmd web md Psychotic Depression. Question: I would like to know what psychotic depression is. Also, I would like to know what schizo-affective disorder is. Thank you very much for your help. Reply: In general, "psychotic depression" is a mental condition where a person is Medical Encyclopdia article about Psychotic depression Psychotic depression. A Medical Encyclopedia Article provided by the University of Maryland resource with information on over 4000 medical topics including: Psychotic depression Psychotic Depression. Question: I would like to know what psychotic depression is. Also, I would like to know what schizo-affective disorder is. Thank you very much for your help. Reply: In general, "psychotic depression" is a mental condition where a person is I do, however, recall that there are several older well-done studies in addition to those below showing that for most patients adding an anti-psychotic is of no benefit in treating psychotic depression. on research on the treatment of psychotic depression or very many of the double-blind Medical Encyclopdia article about Psychotic depression Psychotic depression. A Medical Encyclopedia Article provided by the University of Maryland resource with information on over 4000 medical topics including: Psychotic depression